BIOTECH QUALITY, TECHNOLOGY AND MEDICAL REVOLUTION

BIOTECH QUALITY, TECHNOLOGY AND MEDICAL REVOLUTION

ProtSmartTM

First-class concentrator of proteins and platelets

ProtSmartTM was born from the combination of capillary membrane filtration technology and the concentration of blood pro–ducts. Thanks to a morphology of a properly developed capillary membrane with an average pore size of 15,000 Da, it is possible to eliminate the plasma water, therefore concentrating on the platelets and the growth factors of the plasma. 

A fast, easy and optimized process that only needs one centrifugal phase aimed at the sedimentation of red blood cells, which are later eliminated. PRP and PPP can be concentrated by ProtSmartTM with a volume reduction of about 70%. 

Most plasma proteins that have an important role in promoting regeneration are preserved and concentrated, thanks to the cut-off of capillary membranes.

Filter-Illustration-APR2017_final-(1)

GROWTH FACTORS

Regeneration is inside us

WHAT IS PROTSMARTTM

When infiltered in the area to treat, PRP accelerates the cell proliferation and favors the autologous regeneration of cells and tissues, cicatrization, wound healing, reparation processes, a higher production of fibroblasts and consequently, collagen, and the revascularization of the treated tissues by means of a bio-stimulation process. These regeneration processes have to be stimulated in several different therapeutic applications that range from cosmetic medicine, orthopedics, surgery, etc. 

The PRP and PPP preparation protocols are different from one another, but they generally consist of the collection of autologous blood, the centrifugation of tubes or syringes to separate red blood cells from plasma and other cellular components such as leukocytes and platelets and in isolation (by other followup centrifugations or by means of a selective aspiration) the plasma phase enriched with platelets (PRP) or poor in platelets (PPP).

ProtSmartTM is a hollow capillary membrane that can be used downstream of the blood product’s preparation method in order to concentrate better on the platelets and the plasma proteins of the PPP. The result is a concentration of solutes over a certain molecular weight (greater than the pore size) on one side of the membrane and a loss of liquids and solutes of small size (smaller than the pore size) in the other. This passage is particularly useful if a blood product of high concentrations in small volumes is desired. Indeed, the two available ProtSmartTM models allow one to obtain autologous preparations in few ml with platelet and protein concentrations that achieve 4-6 times compared to the basal concentrations in whole blood.

The concentration occurs with a simple mechanical process and it is aided by the GrowSmart accessory that allows it to push the plasma to be concentrated inside the ProtSmartTM device. During this push phase, the pressure gradient that creates between the two sides of the hollow capillary membrane allows for the overflow of the plasma water from the membrane pores. When the procedure is complete, aspiration recovers the concentrated plasma inside the ProtSmartTM device. 

This concentrate can be used for the infiltration in the area to be treated.

GROWTH FACTORS

Regeneration is inside us

WHAT IS PROTSMARTTM

When infiltered in the area to treat, PRP accelerates the cell proliferation and favors the autologous regeneration of cells and tissues, cicatrization, wound healing, reparation processes, a higher production of fibroblasts and consequently, collagen, and the revascularization of the treated tissues by means of a bio-stimulation process. These regeneration processes have to be stimulated in several different therapeutic applications that range from cosmetic medicine, orthopedics, surgery, etc. 

The PRP and PPP preparation protocols are different from one another, but they generally consist of the collection of autologous blood, the centrifugation of tubes or syringes to separate red blood cells from plasma and other cellular components such as leukocytes and platelets and in isolation (by other followup centrifugations or by means of a selective aspiration) the plasma phase enriched with platelets (PRP) or poor in platelets (PPP).

ProtSmartTM is a hollow capillary membrane that can be used downstream of the blood product’s preparation method in order to concentrate better on the platelets and the plasma proteins of the PPP. The result is a concentration of solutes over a certain molecular weight (greater than the pore size) on one side of the membrane and a loss of liquids and solutes of small size (smaller than the pore size) in the other. This passage is particularly useful if a blood product of high concentrations in small volumes is desired. Indeed, the two available ProtSmartTM models allow one to obtain autologous preparations in few ml with platelet and protein concentrations that achieve 4-6 times compared to the basal concentrations in whole blood.

The concentration occurs with a simple mechanical process and it is aided by the GrowSmart accessory that allows it to push the plasma to be concentrated inside the ProtSmartTM device. During this push phase, the pressure gradient that creates between the two sides of the hollow capillary membrane allows for the overflow of the plasma water from the membrane pores. When the procedure is complete, aspiration recovers the concentrated plasma inside the ProtSmartTM device. 

This concentrate can be used for the infiltration in the area to be treated.

MEDICINE AND COSMETIC SURGERY

ProtSmartTM Plasma is the ideal solution in anti-ageing treatment, as the PRP obtained from the patient’s own blood stimulates the proliferation of skin cells, i.e. fibroblasts, which produce new Collagen, the substance responsible for the quality and elasticity of the skin.

ProtSmartTM Plasma is a device for the further PRP-PPP concentration, which prevents the passage of bacteria, viruses and endotoxins, eliminates water and small size solutes and preserves the plasma proteins by guaranteeing a concentrate even richer in proteins and furtherly enhancing the effects.

When injected in the area to be treated, the PRP accelerates the autologous cellular regeneration, i.e. the bio-stimulation of cells, the regeneration of tissues, cicatrization, wound healing (due to acne and or cosmetic treatments such as laser or peeling), the reparation processes, a higher production of fibroblasts, collagen and the revascularization of skin. 

It is very efficient in treating dark circles around the eyes.

It is useful in fighting wrinkles, decreasing their deepness, making the skin smoother, more compact, firmer, luminous, and fresh, improving the revascularization of the skin tissue, biologically stimulating the skin and regenerating it by revitalizing, firming, moisturizing and renovating the skin so that it rejuvenates by means of a natural renovation process of the cells. 

PRP applications can be performed on the face (periorbital area, cheekbones, forefront, cheeks, lids, chin, nose-lip area), neck and cleavage and on the body (back of the hands, arms, gluteus, hips, abdomen, knees, stretch marks and atrophic scars).

ORTHOPEDICS AND SPORT MEDICINE

ProtSmartTM Plasma is a therapy used as an effective alternative to the surgical solutions for the treatment and healing of lesions, traumas, inflammations and pathologies (i.e. lesions and trauma of ligaments and muscles such as tears and sprains; golfer’s elbow and tennis elbow; tendinitis and Achilles and patellar tendinopathy); for the activation and acceleration of cicatrization and repair and regeneration of skeletal muscle tissues (tendons, bones, muscles, articular cartilage); to prevent and treat decaying and ageing joints and joints in the initial phases of arthrosis. 

It gives a significant improvement of symptoms, a quick reduction of pain, due to the pain killing effect, as well as anti-inflammatory and anti-microbial, and allows a high and fast recovery of functionality.  

MEDICINE AND COSMETIC SURGERY

ProtSmartTM Plasma is the ideal solution in anti-ageing treatment, as the PRP obtained from the patient’s own blood stimulates the proliferation of skin cells, i.e. fibroblasts, which produce new Collagen, the substance responsible for the quality and elasticity of the skin.

ProtSmartTM Plasma is a device for the further PRP-PPP concentration, which prevents the passage of bacteria, viruses and endotoxins, eliminates water and small size solutes and preserves the plasma proteins by guaranteeing a concentrate even richer in proteins and furtherly enhancing the effects.

When injected in the area to be treated, the PRP accelerates the autologous cellular regeneration, i.e. the bio-stimulation of cells, the regeneration of tissues, cicatrization, wound healing (due to acne and or cosmetic treatments such as laser or peeling), the reparation processes, a higher production of fibroblasts, collagen and the revascularization of skin. 

It is very efficient in treating dark circles around the eyes.

It is useful in fighting wrinkles, decreasing their deepness, making the skin smoother, more compact, firmer, luminous, and fresh, improving the revascularization of the skin tissue, biologically stimulating the skin and regenerating it by revitalizing, firming, moisturizing and renovating the skin so that it rejuvenates by means of a natural renovation process of the cells. 

PRP applications can be performed on the face (periorbital area, cheekbones, forefront, cheeks, lids, chin, nose-lip area), neck and cleavage and on the body (back of the hands, arms, gluteus, hips, abdomen, knees, stretch marks and atrophic scars).

ORTHOPEDICS AND SPORT MEDICINE

ProtSmartTM Plasma is a therapy used as an effective alternative to the surgical solutions for the treatment and healing of lesions, traumas, inflammations and pathologies (i.e. lesions and trauma of ligaments and muscles such as tears and sprains; golfer’s elbow and tennis elbow; tendinitis and Achilles and patellar tendinopathy); for the activation and acceleration of cicatrization and repair and regeneration of skeletal muscle tissues (tendons, bones, muscles, articular cartilage); to prevent and treat decaying and ageing joints and joints in the initial phases of arthrosis. 

It gives a significant improvement of symptoms, a quick reduction of pain, due to the pain killing effect, as well as anti-inflammatory and anti-microbial, and allows a high and fast recovery of functionality.  

PERFORMANCE TESTS OF 10 PROTSMARTTM DEVICES

Doc. Laura Mazzucco – Alessandria Hospital blood transfusion center 

Doc. Nadia Dani – BioClarma srl – Turin

Platelets concentration measured in whole blood, in basal PRP and concentrated PRP by ProtsmartTM. 

The concentration of platelets increases about 4 times compared to whole blood and at least 2 times compared to PRP obtained with each centrifugation.

The red dashed lines limit the range of platelet concentration defined by the MD dated 2nd Nov. 2015 as a standard of PRP (1000x10e3/ul ± 20%)

Total protein concentration in basal PRP and concentrated PRP measured by ProtsmartTM. The total plasma proteins including autologous growth factors increase their concentration by about 2.2-3 times compared to the basal PRP concentration obtained by a single centrifugation.

Dosage of the PDGF growth factor (BB isoform as it is more involved in the regeneration processes) by the Bioplex, Biorad, method.

PRP ProtSmart: PRP obtained by the concentration with a ProtSmartTM device;

Basal 2x PRP: PRP obtained by a single centrifugation from whole blood.

PROTSMARTTM 2

PROTSMARTTM 6

PERFORMANCE TESTS OF 10 PROTSMARTTM DEVICES

Doc. Laura Mazzucco – Alessandria Hospital blood transfusion center 

Doc. Nadia Dani – BioClarma srl – Turin

Platelets concentration measured in whole blood, in basal PRP and concentrated PRP by ProtSmartTM. 

The concentration of platelets increases about 4 times compared to whole blood and at least 2 times compared to PRP obtained with each centrifugation.

The red dashed lines limit the range of platelet concentration defined by the MD dated 2nd Nov. 2015 as a standard of PRP (1000x10e3/ul ± 20%)

Total protein concentration in basal PRP and concentrated PRP measured by ProtSmartTM. The total plasma proteins including autologous growth factors increase their concentration by about 2.2-3 times compared to the basal PRP concentration obtained by a single centrifugation.

Dosage of the PDGF growth factor (BB isoform as it is more involved in the regeneration processes) by the Bioplex, Biorad, method.

PRP ProtSmart: PRP obtained by the concentration with a ProtSmartTM device;

Basal 2x PRP: PRP obtained by a single centrifugation from whole blood.

PROTSMART TM 2

PROTSMART TM 6

Copyright

All rights are reserved. No part or image of this document can be reproduced, transmitted, memorized in filing system in any way or method without prior written authorization from Mabelmed Swiss SA – Switzerland. © copyright 2019

Our offices

mabelmed swiss SA
Via Mesolcina 2
6500 Bellinzona
CH-Switzerland

T +41 91 835 40 91

www.mabelmed.swiss
info@mabelmed.swiss

Bäumlihofweg 7
5035 Unterentfelden-Aarau
CH-Switzerland

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Our offices

mabelmed swiss SA
Via Mesolcina 2
6500 Bellinzona
CH-Switzerland

Bäumlihofweg 7
5035 Unterentfelden-Aarau
CH-Switzerland

T +41 91 835 40 91

www.mabelmed.swiss
info@mabelmed.swiss

Follow us on instagram

Copyright

All rights are reserved. No part or image of this document can be reproduced, transmitted, memorized in filing system in any way or method without prior written authorization from Mabelmed Swiss SA – Switzerland. © copyright 2019

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